Biology Animal editing

The use of animals in medical research is widely accepted, though controversial, on the basis that it may help to save human lives and improve quality of life. Recently, however, objections have recently been made specifically to the use of animals in scientific investigation of human so called “lifestyle-related” diseases including cardiovascular disease, obesity, and type II diabetes. One such objection suggests that people themselves are responsible for developing obesity and other ‘lifestyle-related’ diseases. A second objection is that CRISPR-Cas9 gene editing technology and other technical advances have accelerated the creation of engineered animals to meet the specific needs of humans for spare parts, protein production, and therapeutics. The third objection is that the production of animal models of human diseases creates potentially painful, distressful, or otherwise harmful animal states and that such experiments cannot be defended.

You are asked to read the four background articles below and then respond to the prompt questions to begin our discussion.

Write a response to these DISCUSSION PROMPTS in essay format:

Do you think that animals engineered with specific human diseases are more likely to suffer than “traditional” un-engineered organisms?

Should any animal genetic engineering be considered morally impermissible and banned (e.g., research undertaken for human lifestyle improvement purposes)?

What ethical issues should be considered before expanding the use of these technologies in animal species that are not currently used in biomedical research and what would our obligations be toward the quality of life of these animals?

What methods might be required to ensure the humane and ethical care and use of engineered animals, both in the editing phase of their genome as well as in the production and procreation phase of their (and their descendants) lives?

READINGS

Advances in neuroscience imply that harmful experiments in dogs are unethical 2018.pdf

Animal use in pharmacology education and research – The changing scenario 2014.pdf

How welfare biology and commonsense may help to reduce animal suffering 2016.pdf

PETA Study Shows a Staggering Increase in Animal Use in Experiments.pdf

I will attach these readings separately!

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